[abstract] ISOLATION AND IDENTIFICATION OF ZEDERONE AS A MARKER COMPOUND OF CURCUMA AERUGINOSA ROXB. RHIZOME

source: http://resep-herbal.com

By: Yarni L.1, Astuti S.1, Nasrullah I.1, Murhandini S.1, Rahayu WP 1,2

1Research Center for Drug and Food, National Agency for Drug and Food Control
2Department of Food Science and Technology, Bogor Agricultural University

Curcuma aeruginosa Roxb. Rhizome is empirically used as a traditional medicine as carminative, expectorant and for stomachache. Chemical constituents of Curcuma aeruginosa Roxb. Rhizome are 1,8-cineole, curzerenone, furanogermanone, camphor, (2)-3-hexenol, zederone, furanodenone, curcumenol, isocurcumenol, betaelemene, curzerene and germacrone. Chemical examination of n-hexane fraction from column chromatography with n-hexane-ethyl acetate eluen was begun with the isolation of zederone then its structure elucidation was carried out based on spectroscopic evidence by using UV-Vis spectrophotometer, FT-IR, 1H-NMR and 13C-NMR. This zederone will be used as marker to control the quality of traditional medicine products which contain Curcuma aeruginosa Roxb. Rhizome powder extract.

Keywords: Curcuma aeruginosa Roxb. Rhizome, zederone, marker compound

Presented at Seminar and Proceeding the 1st Kamphaeng Saen International Natural Product Symposium, Bangkok-Thailand, October 23-24th 2010

 

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